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Independently of AMP-activated protein kinase, metformin exhibited a dose- and time-dependent inhibition of LNCaP cell survival, a response mitigated by glutathione or N-acetylcysteine (ROS scavengers) treatment

However, Vildagliptin is not indicated as a substitute for insulin in patients requiring insulin

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K., Olayanju, A., Goldring, C

J Biol Chem 291:1664416658 Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X (2023) Copper metabolism in cell death and autophagy

The appetite suppression is strong enough that fasting may feel almost too easya sign to eat deliberately and measure intake rather than relying on hunger cues